Informatics Publishing Limited

K. S. Mohan , B. N. Gangadhar , N. Pradhan , S. M. Channabasavanna

Abstract

The Malignant Neuroleptic Syndrome (MNS) a rare, under diagnosed, but amenable to restitutive measures if recognised early, is here described with a description of six cases which recovered (over a period of three years) once they were recognised early and treated immediately. The cases emphasised the need for early recognition even before the full blown out picture is seen and for immediate treatment once recognized which can avert mortality.

Keywords

Malignant Neuroleptic Syndrome Rigidity Holoperidol Hyperpyrexia Stupor

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H. S. Narayanan , K. S. Mohan , V. K. Radhakrishnan

Abstract

no-abstract

Keywords

Karma, Belief

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H. S. Narayanan , K. S. Mohan , B. S. Sreedhara Rama Rao

Abstract

72 cases of mucopolysaccharidoses were seen in the M. R. Clinic of NIMHANS and of these 58 cases were studied clinically and radiologically. Biochemical investigations were done in each case. Out of the 58 cases, 40 were Hurlers, 14 Hunters' and the remaining 4 were Morquio's. They had all the clinical findings of these categories. A surprising finding was the large number of Hurler's cases as compared to Hunter's which was explained as due to the high consanguinity rate. This study is one of the largest series in the world and should serve to identify cases early so as to help in reducing morbidity with appropriate measures.

Keywords

Mucopolysaccharidoses, Gargoylosm, Hepatosplenomegaly, Mental Retardation

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H. S. Narayanan , K. R. Manjunatha , B. S. Sridhara Rama Rao , S. R. Girimaji , D. H. Gandhi , K. S. Mohan

Abstract

During a survey of over six thousand MR in a decade, we encountered 38 cases, who fitted into the diagnosis of BDLS. The children were brought primarily with the complaint of delayed milestones of development and sluggish physical activity. On examination all showed short stature, microbrachycephaly, synophrys, characteristic nasal changes (triangular tip, lateral prominence and some anteverted nostrils), posterior rotating ears, hirsutism and limitation of extension of elbow. The dermatoglyphic pattern was also suggestive of BDLS. Cytogenetic investigations of 12 patients revealed a normal chromosomal complement. The clinical findings would be reported with points to be kept in mind for differential diagnosis.

Keywords

Brachamann-de Lange Syndrome, Differential Diagnosis, Biochemical, Dermatoglyphics and Cytogenetic Investigations

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P. Lakshmi Reddy , H. S. Narayanan , S. M. Channabasavanna , K. S. Mohan , Sanjeev Sarmukaddam , D. M. Joseph , B. S. Sridhara Rama Rao

Abstract

The family history data obtained from patients with manic depressive psychosis was evaluated to find out the mode of inheritance. The results suggested an autosomal dominant mode of inheritance with incomplete penetrance. The scope of molecular genetics in understanding the nature of inheritance of manic depressive psychosis is indicated.

Keywords

Manic Depressive Psychosis, Autosomal Dominance, Incomplete Penetrance, Molecular Genetics

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